taxonID	type	format	identifier	references	title	description	created	creator	contributor	publisher	audience	source	license	rightsHolder	datasetID
783787C3E5071B65FF47F55A6C86F93C.taxon	http://purl.org/dc/dcmitype/StillImage	image/png	https://zenodo.org/record/7841197/files/figure.png	https://doi.org/10.5281/zenodo.7841197	FIG. 1. Myotis myotis and M. musculus macrophages present differential response to LPS and Poly(I:C) challenge. Change in gene expression of A — IFN-β, B — IL-1β, C — TNF, D — Il-10 in response to LPS and Poly(I:C) treatment at 1, 4 and 24 hr time points are presented as changes in delta Ct values normalized to actin-β. Ratios of the fold induction of anti-inflammatory Il-10 to proinflammatory TNF (E) and Il-1β (F) are also presented. G — Literature derived Il-10/TNF ratios for other mammals. H — NO generated by stimulated M. myotis and mouse macrophages. Bars represent the mean of two experimental repeats ± SEM. Presented P -values indicate the significance of the difference between species from analysis of variance (ANOVA)	FIG. 1. Myotis myotis and M. musculus macrophages present differential response to LPS and Poly(I:C) challenge. Change in gene expression of A — IFN-β, B — IL-1β, C — TNF, D — Il-10 in response to LPS and Poly(I:C) treatment at 1, 4 and 24 hr time points are presented as changes in delta Ct values normalized to actin-β. Ratios of the fold induction of anti-inflammatory Il-10 to proinflammatory TNF (E) and Il-1β (F) are also presented. G — Literature derived Il-10/TNF ratios for other mammals. H — NO generated by stimulated M. myotis and mouse macrophages. Bars represent the mean of two experimental repeats ± SEM. Presented P -values indicate the significance of the difference between species from analysis of variance (ANOVA)	2017-12-01	Kacprzyk, Joanna;Hughes, Graham M.;Palsson-Mcdermott, Eva M.;Quinn, Susan R.;Puechmaille, Sébastien J.;O’Neill, Luke A. J.;Teeling, Emma C.		Zenodo	biologists	Kacprzyk, Joanna;Hughes, Graham M.;Palsson-Mcdermott, Eva M.;Quinn, Susan R.;Puechmaille, Sébastien J.;O’Neill, Luke A. J.;Teeling, Emma C.			
783787C3E5071B65FF47F55A6C86F93C.taxon	http://purl.org/dc/dcmitype/StillImage	image/png	https://zenodo.org/record/7841199/files/figure.png	https://doi.org/10.5281/zenodo.7841199	FIG. 2. Signatures of adaptive evolution in genes involved in sensing of viral infection and activation of antiviral/proinflammatory signalling. Genes under positive selection (site-test) in mammals are highlighted in green. Genes with sites under positive selection in bat lineages are indicated with an asterix	FIG. 2. Signatures of adaptive evolution in genes involved in sensing of viral infection and activation of antiviral/proinflammatory signalling. Genes under positive selection (site-test) in mammals are highlighted in green. Genes with sites under positive selection in bat lineages are indicated with an asterix	2017-12-01	Kacprzyk, Joanna;Hughes, Graham M.;Palsson-Mcdermott, Eva M.;Quinn, Susan R.;Puechmaille, Sébastien J.;O’Neill, Luke A. J.;Teeling, Emma C.		Zenodo	biologists	Kacprzyk, Joanna;Hughes, Graham M.;Palsson-Mcdermott, Eva M.;Quinn, Susan R.;Puechmaille, Sébastien J.;O’Neill, Luke A. J.;Teeling, Emma C.			
783787C3E5071B65FF47F55A6C86F93C.taxon	http://purl.org/dc/dcmitype/StillImage	image/png	https://zenodo.org/record/7841201/files/figure.png	https://doi.org/10.5281/zenodo.7841201	FIG. 3. Bat-specific sites under positive selection in the investigated immune genes. Sites that had statistically significant evidence of positive selection acting across eutherian mammals were investigated for any amino acid substitutions unique to the ancestral bat lineage, the vespertilionid lineage or the pteropodid lineage. Bat lineages-specific sites are highlighted in yellow	FIG. 3. Bat-specific sites under positive selection in the investigated immune genes. Sites that had statistically significant evidence of positive selection acting across eutherian mammals were investigated for any amino acid substitutions unique to the ancestral bat lineage, the vespertilionid lineage or the pteropodid lineage. Bat lineages-specific sites are highlighted in yellow	2017-12-01	Kacprzyk, Joanna;Hughes, Graham M.;Palsson-Mcdermott, Eva M.;Quinn, Susan R.;Puechmaille, Sébastien J.;O’Neill, Luke A. J.;Teeling, Emma C.		Zenodo	biologists	Kacprzyk, Joanna;Hughes, Graham M.;Palsson-Mcdermott, Eva M.;Quinn, Susan R.;Puechmaille, Sébastien J.;O’Neill, Luke A. J.;Teeling, Emma C.			
